Pharmagene PLC (UK): Shares In Issue Update
Changes In FTSE Indices

3 January 2006

Following a shares in issue update for Pharmagene PLC (to be renamed Asterand PLC) (UK), FTSE announces the following changes:

INDEX	CHANGE	EFFECTIVE FROM START OF TRADING
FTSE All-Small	Pharmagene (UK 0923163) will remain in the index with an increased shares in issue total of 100,177,800 and an unchanged investability weighting of 75%.	10 January 2006
FTSE Fledgling	Pharmagene will be treated as above.	10 January 2006
FTSE techMARK 100	Pharmagene will be treated as above.	10 January 2006
FTSE techMARK mediscience	Pharmagene will be treated as above.	10 January 2006

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